Reflection of Collagen Synthesis in Experimental Granulation Tissue on Plasma Protein-Bound Hydroxyproline

Abstract

During the accumulation of collagen in sponge-induced granulomas in rats, the plasma protein-bound hydroxyproline (hyproprotein) increased about two-fold. A rise in plasma non-protein hydroxyproline was also evident. These hydroxyproline fractions returned to the original levels during the involution phase of granuloma. Little change was found in the urinary excretion of hydroxyproline during the experimental period.

Key Words:

• Collagen
• granulation tissue
• granuloma
• hydroxyproline