Renal Inulin Clearance versus Total Plasma Clearance of ⁵¹Cr-EDTA

Abstract

Simultaneous measurements of inulin clearance by infusion and clearance from of ⁵¹Cr-EDTA after single injection were performed in 17 subjects. ⁵¹Cr-EDTA-clearance was calculated as the ratio between plasma volume and the area under the plasma curve from t = o to infinity. Urine collection is not needed. Whole-body counting showed 4.5% retention after 72 hours. The use of ⁵¹Cr-EDTA clearance for deteermination of GFR is justisfied in view of the close correspondence between inulin clearance and plasma clearance of ⁵¹Cr-EDTA.

Key Words:

• ⁵¹Cr-EDTA
• glomerular filtration rate
• inulin
• kidneys
• plasma volume
• radioisotopes
• renal clearance
• tracer kinetics
• total plasma clearance