Excretion of Vanylglycol in Human Urine under Dietary Control, and during Treatment with Antibiotics, Disulfiram, a Monoamineoxidase Inhibitor, Alphamethyldopa and Reserpine

Abstract

Six healthy men were given a fruit- and vegetable-free diet, and one man was given a pure sucrose-water diet and antibiotics for 4 days. Vanylglycol in urine was detected by paper chromatography and thin-layer chroma tography after enzymatic hydrolysis with glusulase (glucuronidase + arylsul fatase). Acid hydrolysis destroyed vanylglycol. Treatment with antibiotics and a sucrose diet did not change the vanylglycol excretion, while the mono amineoxidase inhibitor, alphamethyldopa, and reserpine decreased the excre tion. Disulfiram treatment increased the vanylglycol excretion.

Key Words:

• Alphamethyldopa
• antibiotics
• diet
• disulfiram
• monoamineoxidase inhibitor
• reserpine
• vanylglycol in human urine