Metabolism of Bence Jones Proteins in Non-Myeloma Patients with Normal Renal Function

Abstract

Parameters of 33 turnover studies of Bence Jones proteins in subjects with normal renal function were correlated with immunological type and size of the proteins. The fractional disappearance rates (5–45 per cent per hour) yielded a bimodal distribution. Some Bence Jones protein monomers were catabolized faster than the corresponding dimers. Some seemed to be cata bolized at individually reproducible rates in different recipients. Elimination due to proteinuria was of minor importance.

Key Words:

• Bence Jones protein
• kidney
• kinetics
• macroglobulinaemia
• mol ecular weight
• multiple myeloma
• proteins
• metabolism
• proteinuria
• Stokes radius