The Distribution Volume of ⁸²Br⁻ as a Measurement of the Extracellular Fluid Volume in Normal Persons

Abstract

The distribution volume of ⁸²Br⁻ was determined in normal persons. The time for equilibration was 6 hours after oral, and 4 hours after intravenous, administration of ⁸²Br⁻. Corrections for ⁸²Br⁻ into erythrocytes and urine were shown to be of importance, whereas individual corrections for plasma protein and Gibbs-Donnan's effect were not needed. The reproducibility of the determinations of the distribu tion volume after oral administration showed a standard deviation of 0.547 Iitres per square metre body surface, whereas the standard deviation 4 hours after in travenous administration was 0.124 litres per square metre body surface.

Key Words:

• ⁸²Br⁻-space
• correction factors
• equilibrium time
• extracellular fluid volume
• normals
• reproducibility