Hemodynamic Changes of Adenosine Diphosphate, Adenosine Triphosphate, and Thrombin in Relation to Their Platelet-Aggregating Activity

Abstract

ADP and ATP were infused into the systemic and pulmonary circulation of dogs. Thrombin was infused into the pulmonary circulation. All the agents caused a decreased platelet count. ADP and ATP caused an increase in cardiac output. Pulmonary vascular resistance as well as total peripheral vascular resistance were decreased. Thrombin caused an increase in pulmonary vascular resistance and a decrease in total peripheral vascular resistance.

Key Words:

• ADP
• ATP
• hemodynamics
• platelet aggregation
• thrombin