Serum Alpha₁-Antitrypsin Mass Concentrations in a Finnish Young Male Population

N.-E. Saris Dept. of Clinical Chemistry and Dept. of Pulmonary Diseases, University of Helsinki, Meilahti Hospital, and Central Laboratory of the Finnish Red Cross Blood Service, Helsinki, Finland

Marita A. Nyman Dept. of Clinical Chemistry and Dept. of Pulmonary Diseases, University of Helsinki, Meilahti Hospital, and Central Laboratory of the Finnish Red Cross Blood Service, Helsinki, Finland

E. Varpela Dept. of Clinical Chemistry and Dept. of Pulmonary Diseases, University of Helsinki, Meilahti Hospital, and Central Laboratory of the Finnish Red Cross Blood Service, Helsinki, Finland

H. R. Nevanlinna Dept. of Clinical Chemistry and Dept. of Pulmonary Diseases, University of Helsinki, Meilahti Hospital, and Central Laboratory of the Finnish Red Cross Blood Service, Helsinki, Finland

Abstract

Serum α₁-antitrypsin mass concentrations were estimated in 664 Finnish young males by means of single radial immunodiffusion techniques. The distribution was symmetrical with a mean of 2.70 g/1 and a standard deviation of 0.545 g/1. Sera containing low concentrations were re-analyzed by antigen-antibody-crossed electrophoresis. One serum contained very low levels of α₁-antitrypsin and 34 moderately lowered concentrations corresponding to values seen in Pi-phenotypes ZZ and MZ, respectively. The incidence of serum α₁-antitrypsin deficiency seems to be similar to that found in Scandinavian populations.

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Serum Alpha₁-Antitrypsin Mass Concentrations in a Finnish Young Male Population

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Serum Alpha₁-Antitrypsin Mass Concentrations in a Finnish Young Male Population