In Vitro Determination of Solubility of ¹³³Xenon and ⁸⁵Krypton in Human Liver Tissue with Varying Triglyceride Content

Abstract

The solubility of ¹³³Xe and ⁸⁵Kr in liver tissue with varying lipid content measured enzymatically as triglyceride was determined in vitro. The influence of phospholipids was found to be unimportant. The error of the method is constant (S.D. 0.7) at lipid concentrations below 5%, and increases to about 5 at a hepatic lipid content of 25%. These results can be used for the estimation of hepatic lipid content and perfusion in vivo by the tissue clearances of ¹³³Xe and ⁸⁵Kr.

Key Words:

• Hepatic lipid content
• ⁸⁵Krypton
• solubilities of inert gases
• steatosis of the liver
• tissue clearance methods
• ¹³³Xenon