Sequential Changes of Plasma Proteins after Myocardial Infarction

Abstract

Plasma concentrations of 21 proteins have been determined during three weeks following myocardial infarction. Three major patterns of response were distinguished. (1) C-reactive protein, haptoglobin, antichymotrypsin, fibrinogen, orosomucoid and ai-antitrypsin showed a rapid increase with a maximum on day 5, followed by a partial normalisation on day 21. (2) Prealbumin, albumin, α-lipoprotein, transferrin and immunoglobulin G showed a rapid decrease to 80 % or less on day 5 and restoration to normal values on day 21. (3) Ceruloplasmin and β_1c-globulin showed a moderate increase with maximum during the second week. Only slight changes were found for hemopexin, plasminogen, prothrombin, cold insoluble globulin, β_1F-globulin and a₂-macroglobulin. The immunoglobulin pattern after three weeks was characterized by a small increase most prominent for IgM.

Key Words:

• Acute phase reactants
• immunoglobulins
• inflammation
• myocardial infarction
• plasma proteins