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Abstract
The effect of sodium salicylate on gastric acid secretion has been studied in frog gastric mucosa in vitro, which allows continuous titration of secreted hydrogen ions. When added to either side of the membrane, sodium salicylate diminished both basal and pentagastrin-stimulated acid secretion in a doserelated manner. The dose of submucosal salicylate necessary to produce the same effect as mucosal side addition was approximately twice as high. Evidence is presented which supports the theory that salicylate inhibition of acid secretion may be the result of changes in cell metabolism leading to local uncoupling of oxidative phosphorylation.