A rapid method for the determination of urea stable lactate dehydrogenase on the ‘Cobas Bio’ centrifugal analyser

R. Lund Karlsen Department of Clinical Chemistry, The University Hospital of Akershus, Nordbyhagen, Norway

L. Nørgaard Department of Clinical Chemistry, The University Hospital of Akershus, Nordbyhagen, Norway

E. B. Guldbrandsen Department of Clinical Chemistry, The University Hospital of Akershus, Nordbyhagen, Norway

Abstract

The urea-stable lactate dehydrogenase assay has been adapted to the ‘Cobas Bio’ centrifugal analyser. It was found that incubation of the serum samples with 2 mol/l urea for 2 min was sufficient for inhibition of the LD liver iso-enzymes. Under these conditions enzyme activity of cardiac origin was mainly unaffected. The method is fully automated, rapid and inexpensive.

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A rapid method for the determination of urea stable lactate dehydrogenase on the ‘Cobas Bio’ centrifugal analyser

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A rapid method for the determination of urea stable lactate dehydrogenase on the ‘Cobas Bio’ centrifugal analyser

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