Clinical reliability of measured and calculated oxygen parameters in surgical patients: Influence of hyperventilation

Abstract

The acid-base and oxygen status were assessed in patients undergoing abdominal surgery. We determined the measured and calculated parameters described by Siggaard-Andersen in arterial and mixed venous blood before, during and after a controlled hyperventilation. In these dynamic conditions, the mixed venous calculated p50 showed the most interesting variations. Derived values in arterial blood were unreliable since: 1) fitting to hyperbolic tangent function is not possible when SaO₂ > 0.98; 2) in these patients, the arterio-venous difference in CtO₂ is different from 2.3 mmol/L. The acute changes in calculated p50 are in agreement with the effect of hyperventilation on oxygen status.

Key Words:

• Blood gas monitoring
• calculated parameters
• hyperventilation
• surgical patients.