Urinary concentration of a specific peptide of type I collagen of bone (CrossLaps^TM): correlation to hydroxyproline

Abstract

Urinary bone resorption markers, CrossLaps and hydroxyproline are compared in a non-selected group of 93 women. The correlation between CrossĹaps and hydroxyproline is satisfactory. The r value is 0.79. Furthermore, it is investigated whether CrossLaps can substitute for hydroxyproline in the estimation of bone loss, using a model based on the combination of several biochemical markers. The results indicate that the two systems reflect related or parallel events, and show that CrossLaps is suitable for use in a normal clinical chemistry laboratory.

Key Words:

• biochemical markers
• bone loss
• immunoassay
• osteoporosis