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Abstract
Objective. The pathophysiology of peptic ulcer disease (PUD) in liver cirrhosis (LC) and chronic hepatitis has not been established. The aim of this study was to assess the role of portal hypertension from PUD in patients with LC and chronic hepatitis. Materials and methods. We analyzed the medical records of 455 hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy patients who had LC or chronic hepatitis in a single tertiary hospital. The association of PUD with LC and chronic hepatitis was assessed by univariate and multivariate analysis. Results. A total of 72 PUD cases were detected. PUD was associated with LC more than with chronic hepatitis (odds ratio [OR]: 4.13, p = 0.03). In the univariate analysis, taking an ulcerogenic medication was associated with PUD in patients with LC (OR: 4.34, p = 0.04) and smoking was associated with PUD in patients with chronic hepatitis (OR: 3.61, p = 0.04). In the multivariate analysis, taking an ulcerogenic medication was associated with PUD in patients with LC (OR: 2.93, p = 0.04). However, HVPG was not related to PUD in patients with LC or chronic hepatitis. Conclusion. According to the present study, patients with LC have a higher risk of PUD than those with chronic hepatitis. The risk factor was taking ulcerogenic medication. However, HVPG reflecting portal hypertension was not associated with PUD in LC or chronic hepatitis (Clinicaltrial number NCT01944878).
Acknowledgments
Conception and design of the study: Chang Seok Bang, Gwang Ho Baik, Jong Hyeok Kim. Generation, collection, assembly, analysis, and/or interpretation of data: Chang Seok Bang, Jin Bong Kim, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim. Drafting or revision of the manuscript: Chang Seok Bang, Jong Hyeok Kim, Dong Joon Kim. Approval of the final version of the manuscript: Gwang Ho Baik, Jong Hyeok Kim. Writing Assistance: English editing was done by the editing company (www.aje.com). There was no funding source relevant to this editing of article.
Declaration of interest: The authors disclose no financial relationship relevant to this publication. There was no financial or grant support related to this article.