Neoplasia in the colorectal specimens of patients with ulcerative colitis and ileal pouch-anal anastomosis – need for routine surveillance?

Abstract

Objective. Patients who undergo ileal pouch-anal anastomosis (IPAA) after colectomy for ulcerative colitis (UC) occasionally have neoplasia in the IPAA. Patients with evidence of dysplasia or carcinoma in the colorectal specimen may have an increased risk of such neoplasia. A surveillance program has been suggested. The aims of this study were to evaluate the outcomes of surveillance of a large patient cohort, and to investigate the prevalences of neoplasia in the ileal pouch mucosa and in the anal transitional zone (ATZ). Material and methods. A total of 629 patients underwent IPAA for UC at Sahlgrenska University Hospital, Gothenburg, Sweden. Identified from a register, 73 patients with neoplasia in their specimen considered eligible for the trial were prospectively enrolled, and underwent clinical examination, endoscopy with macroscopic evaluation, and mucosal biopsies from the ileal pouch and the ATZ. The biopsies were independently evaluated by two experienced gastro-pathologists. Results. In all, 56 patients (39 males) with a median follow-up time of 18 (range, 1–29) years were evaluated. One patient (1.8%; 95% CI 0%–5.3%) showed low-grade dysplasia in the pouch, as recorded by one of the two pathologists. The individual pathologists recorded indefinite for dysplasia (IFD) in the pouch for 19 and 20 patients, respectively, and IFD in the ATZ for 2 and 4 patients, respectively. None of the biopsies showed evidence of high-grade dysplasia (HGD) or carcinoma. Conclusions. Neoplasia in the ileal pouch or ATZ after IPAA for UC is rare in the proposed risk group. The necessity for and value of a routine surveillance program should be prospectively evaluated.

Key Words:

• carcinoma
• dysplasia
• IPAA
• neoplasia
• risk factors
• surveillance
• ulcerative colitis

Acknowledgments

The authors thank the following for assessing patients at sites outside of Sahlgrenska University Hospital: Dr. Mattias Prytz, NÄL Hospital, Trollhättan; Dr. George Dafnis, Eskilstuna Hospital; and Dr. Lars Kjellson, Karlstad Hospital. This study was supported by grants from the Medical Society of Gothenburg, Sweden, and the Bror Björnsson Research Foundation, Gothenburg, Sweden.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.