The Effects of Beta-Adrenergic Receptor Blockade on the Inhibition of Gastric Acid Secretion, and the Release of Pancreatic Polypeptide by Antral Distension in Healthy Subjects

I.-M. Schöön Dept. of Surgery II, Sahlgren's Hospital, Gothenburg, and Research Laboratories, AB Hässle, Mölndal, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

P. Lundborg Dept. of Surgery II, Sahlgren's Hospital, Gothenburg, and Research Laboratories, AB Hässle, Mölndal, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

T. W. Schwartz Dept. of Surgery II, Sahlgren's Hospital, Gothenburg, and Research Laboratories, AB Hässle, Mölndal, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

L. Olbe Dept. of Surgery II, Sahlgren's Hospital, Gothenburg, and Research Laboratories, AB Hässle, Mölndal, Sweden, and Institute of Medical Biochemistry, University of Aarhus, Aarhus, Denmark

Abstract

In a randomized double-blind study of seven healthy subjects an intravenous injection of metoprolol and propranolol did not change the submaximal gastric acid response to pentagastrin. The inhibition of pentagastrin-stimulated acid secretion by balloon distension of the antrum was unchanged by a preceding intravenous injection of metoprolol or propranolol. The plasma level of pancreatic polypeptide in peripheral venous blood showed a significant rise during antral distension. This rise was unaltered by a preceding injection of metoprolol and slightly depressed by propranolol. We conclude that the inhibitory effect of antral distension on gastric acid secretion in healthy subjects is not mediated by β₁ or β₂-adrenergic mechanisms. The reflex release of pancreatic polypeptide by antral distension may possibly involve a weak β₂-adrenergic component.

Key words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The Effects of Beta-Adrenergic Receptor Blockade on the Inhibition of Gastric Acid Secretion, and the Release of Pancreatic Polypeptide by Antral Distension in Healthy Subjects

Information for

Open access

Opportunities

Help and information

The Effects of Beta-Adrenergic Receptor Blockade on the Inhibition of Gastric Acid Secretion, and the Release of Pancreatic Polypeptide by Antral Distension in Healthy Subjects

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature