Effect of Dopamine on Pentagastrin-Stimulated Gastric Antral Motility in Dogs with Gastric Fistula

Abstract

The purpose of the present study was to evaluate the effect of dopamine on gastric antral motility in conscious dogs with gastric fistula by using miniature strain-gauge transducers. Infusion of pentagastrin changed the contractile activity to a digestive state. Dopamine, an endogenous catecholamine, was used alone and in conjunction with selective blockade of adrenergic and dopaminergic receptors. The stimulated antral motility was inhibited by dopamine. The effect was significantly blocked by the peripherally acting dopaminergic blocker domperidone and by cis-flupenthixol. which blocks both peripheral and central dopaminergic receptors. The effect of dopamine was not significantly altered by the β₁-adrenoceptor blocker practolol, the α-adrenoceptor blocker phentolamine, or the α- + β-adrenoceptor blocker labetalol. Consequently, this study indicates that dopamine acts on gastric antral motility through dopaminergic receptors. β-adrenergic receptors, which are active in the impairment of gastric acid secretion, seem not to be involved in the motility response.

Key-words:

• α-, α + β-, β₁-Adrenoceptor blocking drugs
• dogs
• dopamine
• dopaminergic blocking drugs
• gastric antral motility
• pentagastrin
• strain-gauge transducer