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Scandinavian Journal of Gastroenterology Volume 17, 1982 - Issue 4
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Original Article

The Effects of Secretagogues on Isolated Human Gastric Glands

U. Haglund Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, and Dept. of Biochemistry, AB Hässle, Mölndal, Sweden
,
B. Elander Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, and Dept. of Biochemistry, AB Hässle, Mölndal, Sweden
,
E. Fellenius Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, and Dept. of Biochemistry, AB Hässle, Mölndal, Sweden
,
R. Leth Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, and Dept. of Biochemistry, AB Hässle, Mölndal, Sweden
,
O. Rehnberg Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, and Dept. of Biochemistry, AB Hässle, Mölndal, Sweden
&
L. Olbe Dept. of Surgery II, Sahlgren's Hospital, University of Gothenburg, Gothenburg, and Dept. of Biochemistry, AB Hässle, Mölndal, Sweden
Pages 455-460 | Received 11 Sep 1981, Accepted 02 Nov 1981, Published online: 19 Feb 2010
 
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Abstract

The function of isolated human gastric glands has been studied in vitro by measuring the 14C-aminopyrine accumulation (RAP) in basal, unstimulated, conditions and after stimulation with different secretagogues. A microscale technique was used which enabled determinations of RAP in tissue obtained as gastroscopic biopsies. In addition, oxyntic-gland-containing mucosa was obtained at gastric resections for gastric or prepyloric ulcer disease. Histamine and cAMP derivative both induced maximal stimulation; RAP was approximately three times larger than in basal states. Carbachol induced a smaller but still significant stimulation. Pentagastrin did not increase RAP above the unstimulated level. Combinations of histamine and carbachol or pentagastrin did not induce a larger response than carbachol alone. The peak acid response to pentagastrin or betazole in vivo did not correlate with the maximum RAP in vitro.

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