Release of Gastric Inhibitory Polypeptide and Insulin in Response to Intrajejunal Glucose in Duodenal Ulcer Patients before and after Truncal Vagotomy

Abstract

Six duodenal ulcer patients were investigated before and 3 months after truncal vagotomy and pyloroplasty. Plasma concentrations of gastric inhibitory polypeptide (GIP), insulin, and glucose were measured during intrajejunal infusion of 50 g of glucose. The GIP response was significantly diminished postoperatively; insulin and glucose concentrations, however, were unchanged. The reduction of GIP release was positively correlated with the reduction of the peak acid output. The results suggest that a reduced vagal innervation of the intestine is accompanied by reduced GIP release after intrajejunal glucose, depending on the degree of completeness of vagotomy.

Key words:

• Duodenal ulcer
• gastric inhibitory polypeptide (GIP)
• glucose
• insulin
• vagotomy