The Correlation between Gastric Emptying Time and the Response of GIP and Enteroglucagon to Oral Glucose in Duodenal Ulcer Patients

K. B. Lauritsen Dept. of Surgical Gastroenterology and Dept. of Clinical Physiology, Hvidovre Hospital, and Institute of Medical Physiology C, University of Copenhagen, Copenhagen, Denmark

H.-J. Frederiksen Dept. of Surgical Gastroenterology and Dept. of Clinical Physiology, Hvidovre Hospital, and Institute of Medical Physiology C, University of Copenhagen, Copenhagen, Denmark

A. Uhrenholdt Dept. of Surgical Gastroenterology and Dept. of Clinical Physiology, Hvidovre Hospital, and Institute of Medical Physiology C, University of Copenhagen, Copenhagen, Denmark

J. J. Holst & Hup HUP = Hvidovre Hospital's Ulcer Project. Members are Peter Matzen, Povl Madsen, Ebbe Kragelund, Einar Krag, Poul M. Christiansen, Olaf Bonnevie.

Abstract

Simultaneous 50-g oral glucose tolerance tests and measurements of gastric emptying time were performed in 11 duodenal ulcer patients. Gastric emptying time, measured by the gamma-camera technique, and the response of gastric inhibitory polypeptide (GIP) and enteroglucagon to the oral load showed a significant negative correlation. The GIP response and the insulinogenic index were significantly positively correlated. It is concluded that the increased GIP and insulin response to glucose among duodenal ulcer patients may be explained by increased gastric emptying, known to occur in these patients. The study has not given new information on the possible physiological role of enteroglucagon.

Key words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

The Correlation between Gastric Emptying Time and the Response of GIP and Enteroglucagon to Oral Glucose in Duodenal Ulcer Patients

Information for

Open access

Opportunities

Help and information

The Correlation between Gastric Emptying Time and the Response of GIP and Enteroglucagon to Oral Glucose in Duodenal Ulcer Patients

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature