Evaluation of Gliadin Antibodies for Detection of Coeliac Disease

A. F. Kilander Section for Medical Gastroenterology, Dept. of Medicine II. Sahlgren's Hospital; Dept. of Paediatrics I, Östra sjukhuset; Dept. of Clinical Immunology; and Dept. of Microbiology; University of Gothenburg, Gothenburg, Sweden

G. Dotevall Section for Medical Gastroenterology, Dept. of Medicine II. Sahlgren's Hospital; Dept. of Paediatrics I, Östra sjukhuset; Dept. of Clinical Immunology; and Dept. of Microbiology; University of Gothenburg, Gothenburg, Sweden

S. P. Fällström Section for Medical Gastroenterology, Dept. of Medicine II. Sahlgren's Hospital; Dept. of Paediatrics I, Östra sjukhuset; Dept. of Clinical Immunology; and Dept. of Microbiology; University of Gothenburg, Gothenburg, Sweden

R. E. Gillberg Section for Medical Gastroenterology, Dept. of Medicine II. Sahlgren's Hospital; Dept. of Paediatrics I, Östra sjukhuset; Dept. of Clinical Immunology; and Dept. of Microbiology; University of Gothenburg, Gothenburg, Sweden

L.-Å. Nilsson Section for Medical Gastroenterology, Dept. of Medicine II. Sahlgren's Hospital; Dept. of Paediatrics I, Östra sjukhuset; Dept. of Clinical Immunology; and Dept. of Microbiology; University of Gothenburg, Gothenburg, Sweden

A. Tarkowski Section for Medical Gastroenterology, Dept. of Medicine II. Sahlgren's Hospital; Dept. of Paediatrics I, Östra sjukhuset; Dept. of Clinical Immunology; and Dept. of Microbiology; University of Gothenburg, Gothenburg, Sweden

Abstract

To evaluate assay of gliadin antibodies of different immunoglobulin classes as a test for detection of coeliac disease, we analysed sera from 36 adult patients and 8 children with coeliac disease, 62 patients with other gastrointestinal diseases, and 124 blood donors with diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA). Depending on the choice of reference levels for gliadin antibodies of the IgA and IgG classes, respectively, we found a diagnostic sensitivity for coeliac disease of 93-86% and a diagnostic specificity of 95-100%. Determination of gliadin antibodies by DIG-ELISA can thus be used as a test for detection of coeliac disease and selection of patients for small-intestinal biopsy.

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Evaluation of Gliadin Antibodies for Detection of Coeliac Disease

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Evaluation of Gliadin Antibodies for Detection of Coeliac Disease

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