Indomethacin Treatment of Acute Pancreatitis: A Controlled Double-Blind Trial

N. Ebbehøj Dept. of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre; Surgical Dept. K, Frederiksberg Hospital, Frederiksberg, Denmark

J. Friis Dept. of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre; Surgical Dept. K, Frederiksberg Hospital, Frederiksberg, Denmark

L. B. Svendsen Dept. of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre; Surgical Dept. K, Frederiksberg Hospital, Frederiksberg, Denmark

S. Bülow Dept. of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre; Surgical Dept. K, Frederiksberg Hospital, Frederiksberg, Denmark

P. Madsen Dept. of Surgical Gastroenterology, Hvidovre Hospital, University of Copenhagen, Hvidovre; Surgical Dept. K, Frederiksberg Hospital, Frederiksberg, Denmark

Abstract

Thirty patients with acute pancreatitis were allocated to indomethacin suppositories, 50 mg twice daily, or identical-looking placebo suppositories for 7 days in a controlled double-blind trial. The groups of patients were not different with regard to age, sex, etiology, or number of Ranson criteria. The number of days with pain and number of opiate injections were significantly less in patients treated with indomethacin. The median values of serum amylase and serum calcium were not different before or at any day during treatment. Bleeding from the gastrointestinal tract was not seen.

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Indomethacin Treatment of Acute Pancreatitis: A Controlled Double-Blind Trial

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Indomethacin Treatment of Acute Pancreatitis: A Controlled Double-Blind Trial

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