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Scandinavian Journal of Gastroenterology Volume 23, 1988 - Issue 10
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Original Article

Tripotassium Dicitrate Bismuthate and Ranitidine in Duodenal Ulcer: Healing and Influence on Recurrence

G. Bianchi Porro Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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M. Lazzaroni Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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L. Barbara Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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R. Corinaldesi Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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P. R. Dal Monte Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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N. D'imperio Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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G. Mazzacca Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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A. D'arienzo Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
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R. Cheli Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
&
E. Bovero Gastrointestinal Unit, Ospedale L. Sacco, Milan; 3rd Medical Clinic, University of Bologna, Dept. of Gastroenterology, Ospedale Bellaria, Bologna; Dept. of Gastroenterology, University of Naples, Naples; Dept. of Gastroenterology, Ospedale San Martino, Genoa, Italy
 show all
Pages 1232-1236 | Received 03 May 1988, Accepted 10 Aug 1988, Published online: 08 Jul 2009
 
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Abstract

One hundred patients were entered into a double-blind, double-dummy comparison of tripotassium dicitrate bismuthate (TDB) versus ranitidine, to evaluate short-term healing rates, and successfully healed patients were then entered into a follow-up phase to observe relapse rates. At 4 weeks 84% of patients treated with TDB and 68% of those treated with ranitidine had healed. At 8 weeks these figures had risen to 96% and 90%, respectively (p = NS). After a year's follow-up study 84% of patients healed initially with ranitidine had relapsed, whereas in the case of patients healed initially with TDB the relapse rate was 67% (p < 0.05). The results confirm that in the short term, TDB is as effective as ranitidine, whereas the significantly better protection against relapse offered by TDB compared with ranitidine underlines the importance of restoring mucosal defence, an approach that to date has been somewhat overlooked.

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