Colorectal Adenomas and Food: A Prospective Study of Change in Volume and Total Mass of Adenomas in Man

G. Hoff Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

I. E. Moen Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

K. Trygg Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

W. Frölich Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

A. Foerster Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

M. Vatn Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

J. Sauar Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

S. Larsen Medical Dept., Telemark Sentralsykehus, Skien, Norway; Medical Dept., Ullevål Hospital, Oslo, Norway; University of Oslo, Oslo, Norway; Dept. of Pathology and Medical Dept. A, Rikshospitalet, Oslo, Norway; Medstat, Strømmen, Norway

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Abstract

In an endoscopic population screening study for detection of colorectal polyps the diet was registered before ascertaining whether polyps were present. Polyps < 5 mm in diameter were followed up for 2 years before removal and histologic diagnosis. The relative risk of an increase both in the volume of registered adenomas (excluding new adenomas) and in the total mass of adenomas (including new adenomas) showed a trend towards an inverse relationship with intake of dietary fiber, non-fiber carbohydrate, and cruciferous vegetables, reaching the significance level only for intake of dietary fiber for increase of adenoma volume in men. A trend towards a positive relationship between growth and total fat intake was more inconsistent, although the significance level was reached for the relative risk of increase in adenoma mass for men. These prospective observations with regard to polyp-bearing individuals agree with previous incidence and prevalence data that have indicated a relationship between dietary habits and colorectal carcinogenesis.

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Colorectal Adenomas and Food: A Prospective Study of Change in Volume and Total Mass of Adenomas in Man

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Colorectal Adenomas and Food: A Prospective Study of Change in Volume and Total Mass of Adenomas in Man

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