Increased in Vitro Tetraploidy and Mandibular Osteomas in Patients with and without Colorectal Diseases

L. B. Svendsen Dept. of Surgicai Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark; Dept. of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Institute of Medical Genetics, Odense University Hospital, Odense, Denmark; Laboratory for Cell Biology Dept. of Medicine, Cornell Medical School, New city, USA

J. O. Søndergaard Dept. of Surgicai Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark; Dept. of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Institute of Medical Genetics, Odense University Hospital, Odense, Denmark; Laboratory for Cell Biology Dept. of Medicine, Cornell Medical School, New city, USA

S. Bulow Dept. of Surgicai Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark; Dept. of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Institute of Medical Genetics, Odense University Hospital, Odense, Denmark; Laboratory for Cell Biology Dept. of Medicine, Cornell Medical School, New city, USA

K. B. Lauritsen Dept. of Surgicai Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark; Dept. of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Institute of Medical Genetics, Odense University Hospital, Odense, Denmark; Laboratory for Cell Biology Dept. of Medicine, Cornell Medical School, New city, USA

N. V. Holm Dept. of Surgicai Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark; Dept. of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Institute of Medical Genetics, Odense University Hospital, Odense, Denmark; Laboratory for Cell Biology Dept. of Medicine, Cornell Medical School, New city, USA

B. Shannon Danes Dept. of Surgicai Gastroenterology, Hvidovre Hospital, Hvidovre, Denmark; Dept. of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; Institute of Medical Genetics, Odense University Hospital, Odense, Denmark; Laboratory for Cell Biology Dept. of Medicine, Cornell Medical School, New city, USA

Abstract

One hundred and seventy-six individuals with various colorectal diseases were investigated simultaneously for increased in vitro tetraploidy in dermal fibroblast cultures and for occult mandibular osteomas. In only 10 of the 176 persons were both presumed markers of colorectal genetic predisposition present in the same individual. No evidence was found that these traits are causally associated. A combination of the two presumed markers showed a tendency towards occurrence in individuals with a positive family history of colorectal cancer among first-degree relatives.

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Increased in Vitro Tetraploidy and Mandibular Osteomas in Patients with and without Colorectal Diseases

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Increased in Vitro Tetraploidy and Mandibular Osteomas in Patients with and without Colorectal Diseases

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