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Original Article

Evaluation of Magnesium Status in Crohn's Disease as Assessed by Intracellular Analysis and Intravenous Magnesium Infusion

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Pages 555-561 | Received 14 Oct 1987, Accepted 11 Jan 1988, Published online: 08 Jul 2009
 

Abstract

The magnesium status was evaluated in 30 subjects with Crohn's disease and in 30 controls. Subjects with Crohn's disease had lower concentrations of magnesium in muscle biopsy specimens (p < 0.001), mononuclear cells (p<0.05), and in urine collected during 24 h (p < 0.001) as compared with controls. After intravenous infusion of 60 mmol magnesium and 80 mmol potassium to 17 subjects with Crohn's disease a significant increase in concentrations of magnesium in muscle specimens (p < 0.05), mononuclear cells (p < 0.01), and plasma (p < 0.01) was noted. The retention of intravenously infused magnesium was significantly higher in subjects with Crohn's disease than in 11 healthy controls (p < 0.001) and was inversely correlated with the content of magnesium in muscle specimens (r = -0.52; p < 0.05). The implication of these findings is that analysis of magnesium in muscle specimens and estimation of magnesium retention during an intravenous magnesium infusion are useful to confirm a suspected magnesium deficiency.

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