Glucagon and Insulin for the Treatment of Hepatic Failure in Dimethylnitrosamine-Intoxicated Rats

K. Fujiwara First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

I. Ogata First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

S. Mishiro First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

Y. Ohta First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

Y. Oka First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

K. Takatsuki First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

Y. Sato First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

S. Hayashi First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

S. Yamada First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

H. Oka First Dept. of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo, Japan

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Abstract

When rats received dimethylnitrosamine every 24 h until death, plus hormone treatment after the first 24 h, the survival was enhanced between 100 and 140 h compared with the control rats, with attenuated derangements of prothrombin time and serum albumin levels at 120 h. In rats given a single dose of dimethylnitrosamine, hepatic DNA synthesis peaked at 48 h. The synthesis was increased after hormone treatment when started immediately, but not when delayed for 24 h. Hormone treatment for 3 days starting 24 h after a single dose of dimethylnitrosamine produced a rapid normalization of decreased hepatic protein content on day 9, although hepatic DNA content was not affected. These results suggest that this treatment is effective for hepatic failure, and the promotion of restoration of liver function is a contributing factor to its effect, in addition to the stimulation of hepatocyte proliferation.

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Glucagon and Insulin for the Treatment of Hepatic Failure in Dimethylnitrosamine-Intoxicated Rats

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Glucagon and Insulin for the Treatment of Hepatic Failure in Dimethylnitrosamine-Intoxicated Rats

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