Role of Lipid Peroxidation and Oxygen Radicals in Compound 48/80-Induced Gastric Mucosal Injury in Rats

T. Takemura First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

T. Yoshikawa First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

N. Yoshida First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

H. Takano First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

N. Tasaki First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

Y. Naito First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

S. Ueda First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

S. Sugino First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

M. Kondo First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

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Abstract

Repeated administration of a small dose of compound 48/80 induced acute gastric mucosal injury in rats. Thiobarbituric acid (TBA) reactants in the gastric mucosa were significantly increased and serum a-tocopherol was significantly decreased after the treatment. The total area of gastric lesions and the increase in TBA reactants in the gastric mucosa were significantly reduced by pretreatment with superoxide dismutase (SOD) and/or catalase, allopurinol and anti-rat polymorphonuclear leukocytes (PMN) antibody. Lipid peroxidation and oxygen radicals derived from both the xanthine-xanthine oxidase system and PMN may be involved in the pathogenesis of compound 48/80-induced gastric mucosal injury.

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Role of Lipid Peroxidation and Oxygen Radicals in Compound 48/80-Induced Gastric Mucosal Injury in Rats

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Role of Lipid Peroxidation and Oxygen Radicals in Compound 48/80-Induced Gastric Mucosal Injury in Rats

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