Role of Free Radicals and Lipid Peroxidation in Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

S. Ueda First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

T. Yoshikawa First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

S. Takahashi First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

H. Ichikawa First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

M. Yasuda First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

H. Oyamada First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

T. Tanigawa First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

S. Sugino First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

M. Kondo First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

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Abstract

Ischemia and reperfusion are of the greatest importance in the pathology of many diseases. We investigated the roles of oxygen-derived free radicals and lipid peroxidation in gastric mucosal injury, such as spotty and linear hemorrhagic erosions, induced in rats by ischemia-reperfusion. The gastric mucosal injury and the increase in thiobarbituric acid (TBA) reactants in the gastric mucosa induced by ischemia-reperfusion were significantly inhibited by treatment with SOD and catalase. These results suggest that oxygen-derived free radicals and lipid peroxidation play important roles in the pathogenesis of acute gastric mucosal lesions induced by ischemia-reperfusion.

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Role of Free Radicals and Lipid Peroxidation in Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

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Role of Free Radicals and Lipid Peroxidation in Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

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