Role of PAF in Ischemia-Reperfusion Injury in the Rat Stomach

A. Iwai First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

M. Itoh First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

Y. Yokoyama First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

N. Yasue First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

T. Miyamoto First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

T. Joh First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

K. Matsusako First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

K. Endoh First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

T. Kawai First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

T. Takeuchi First Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan

show all

Abstract

Ischemia-reperfusion induced extensive gastric mucosal injury and an increase in chemiluminescence activity of neutrophils obtained from the portal vein in hemorrhagic shock rats. CV-3988, a selective antagonist of platelet activating factor (PAF), significantly reduced the gross and histologic gastric damage, and the increase in chemiluminescence activity of neutrophils. These results suggest that PAF generated on hypoxia might stimulate oxygen radical production by neutrophils, resulting in the occurrence of gastric injury in hemorrhagic shock rats.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Role of PAF in Ischemia-Reperfusion Injury in the Rat Stomach

Information for

Open access

Opportunities

Help and information

Role of PAF in Ischemia-Reperfusion Injury in the Rat Stomach

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature