The Relationship between Adaptive Cytoprotection and Prostaglandin Contents in the Rat Stomachs after Oral Administration of 0.35 N HCI

Abstract

Oral administration of a mild irritant, 0.35 N HCI, protected the gastric mucosa of rats against 0.6 N HC1-induced gastric lesions for 2 h. With prior administration of 0.35 N HCI, the PGE₂ and PGF_2a contents in the fundic mucosa, as measured with a capillary gas chro-matograph and a mass spectrometer, significantly increased until 1 h, but the PGD₂, 6-keto-PGF_la and TXB₂ contents did not increase. These results suggest that the increases in gastric mucosal PG contents caused by the mild irritant protect the gastric mucosa against the strong irritant indirectly.

Key Words:

• Adaptive cytoprotection
• HCl-induced gastric lesions
• prostaglandin contents