Physiological Significance of Mucous Neck Cell-type Mucins in the Healing of Acetic Acid-induced Gastric Ulcers in Rats

A. Sugiyama First Department of Surgery, and Department of Laboratory Medicine, Shinsyu University School of Medicine, Matsumoto, Japan

H. Ichikawa First Department of Surgery, and Department of Laboratory Medicine, Shinsyu University School of Medicine, Matsumoto, Japan

C. Kobayashi First Department of Surgery, and Department of Laboratory Medicine, Shinsyu University School of Medicine, Matsumoto, Japan

Y. Hashikura First Department of Surgery, and Department of Laboratory Medicine, Shinsyu University School of Medicine, Matsumoto, Japan

T. Katsuyama First Department of Surgery, and Department of Laboratory Medicine, Shinsyu University School of Medicine, Matsumoto, Japan

Abstract

The present study was undertaken to elucidate the role of mucous secreting cells in the healing of acetic acid-induced gastric ulcers in rats. The results indicated that mucous neck cells (MNCs) and their secretions seem to play important roles in the prevention of the expansion of ulceration in the early stage. The reasons are that the surface mucous layer coating the ulcerated surface almost exclusively consists of MNC-type mucins and MNCs increase markedly in the mucosae surrounding ulcers. Transitional type cells containing both MNC-type and chief cell-type granules frequently occurred in this region, although chief cells almost completely disappeared.

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Physiological Significance of Mucous Neck Cell-type Mucins in the Healing of Acetic Acid-induced Gastric Ulcers in Rats

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Physiological Significance of Mucous Neck Cell-type Mucins in the Healing of Acetic Acid-induced Gastric Ulcers in Rats

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