Mechanism of Anti-Ulcer Effect of Calf Blood Extract

Abstract

The mechanism of anti-ulcer effect of Solcoseryl, an extract from calf blood, was studied. Solcoseryl (10 ml/kg, i. v.) increased basal and chemically reduced potential difference of the gastric mucosa in rats. Solcoseryl (1-10 ml/kg, i.v.) also increased gastric mucosal blood flow and gastroduodenal HCO₃- secretion. These results indicate that Solcoseryl has a mucosal protective effect which may contribute to the mechanism of its anti-ulcer effect.

Key Words:

• Anti-ulcer effect
• gastric mucosal blood flow
• gastric mucosal potential difference
• gastroduodenal HCCy secretion
• solcoseryl