Effects of ALE-36 on Gastric Secretion, and Gastric and Duodenal Ulcers Induced in Rats

Abstract

We examined the antisecretory and anti-ulcer effects of ALE-36 in rats. ALE-36 (3-30 mg/kg) dose-dependently inhibited gastric acid secretion in pylorus-ligated rats. However, the agent apparently increased the volume of gastric juice, and the Na⁺ and CI- ion outputs. These changes were almost completely prevented by pretreat-ment with indomethacin, suggesting that endogenous prostaglandins in the gastric mucosa mediated the changes. Pretreatment with ALE-36 (3-30 mg/kg) inhibited the development of stress-, aspirin-, and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcers. Repeated administration of ALE-36 significantly accelerated the healing of gastric ulcers induced by thermocautery.

Key Words:

• ALE-36 [methyl (E)-2-(3, 4-dimethoxystyryl)-benzimidazole-4-carboxylate]
• duodenal lesions
• gastric lesions
• gastric secretion
• ulcer healing