The Effect of DQ-2511, a Newly Synthesized Anti-Ulcer Drug, on the Gastric Mucosal Hemodynamics and Ulceration in Rats

H. Tanimura Department of Medicine, Osaka University Medical School, Osaka, Japan

N. Sato Department of Medicine, Osaka University Medical School, Osaka, Japan

S. Kawano Department of Medicine, Osaka University Medical School, Osaka, Japan

M. Tsujii Department of Medicine, Osaka University Medical School, Osaka, Japan

N. Hayashi Department of Medicine, Osaka University Medical School, Osaka, Japan

H. Sakura Department of Medicine, Osaka University Medical School, Osaka, Japan

S. Tsujii Department of Medicine, Osaka University Medical School, Osaka, Japan

T. Ogihara Department of Medicine, Osaka University Medical School, Osaka, Japan

T. Kamada Department of Medicine, Osaka University Medical School, Osaka, Japan

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Abstract

DQ-2511, which is a dopamine derivative, is a newly synthesized anti-ulcer drug. Pretreatment with DQ-2511 in the hemorrhagic shock-reperfusion model in rats significantly prevented the decreases of gastric mucosal blood volume, mucosal blood oxygenation index and the ulcer formation. The decrease in gastric mucosal blood oxygenation index in hemorrhagic shock state has a linear correlation with the size of the mucosal ulcers both in DQ-2511 and control groups. The results suggested that DQ-2511 exerts its anti-ulcer activity by improving mucosal hemodynamics in hemorrhagic shock-reperfusion rat model.

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The Effect of DQ-2511, a Newly Synthesized Anti-Ulcer Drug, on the Gastric Mucosal Hemodynamics and Ulceration in Rats

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The Effect of DQ-2511, a Newly Synthesized Anti-Ulcer Drug, on the Gastric Mucosal Hemodynamics and Ulceration in Rats

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