Effects of hEGF (MG111) on Gastric Mucosal Potential Difference in Rats

R. Azuma Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

K. Gotoh Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

Y. Yamazaki Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

M. Sugiyama Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

H. Katamura Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

T. Ishikawa Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

C. Kunisaki Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

S. Tsuchiya Ibaraki Research Laboratory, Hitachi Chemical Co., Ltd., Hitachi, Ibaraki, 317, Japan; Second Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan

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Abstract

hEGF (MG111) given i. v. significantly and dose-dependently suppressed the reduction in gastric mucosal potential-difference (PD) induced by 30 % ethanol in rats. Pretreatment with indomethacin did not affect its effect, thereby suggesting that endogenous prostaglandins will not be involved in the mechanism of action of MG111. These results indicate that MG111 protects the weakening of “gastric mucosal barrier”. The PD was significantly reduced when MG111 was given i. v. at 20 μg/kg. This reduction caused by MG111 was not affected by pretreatment with atropine, hexamethonium, propranolol, and phentolamine.

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Effects of hEGF (MG111) on Gastric Mucosal Potential Difference in Rats

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Effects of hEGF (MG111) on Gastric Mucosal Potential Difference in Rats

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