Signet Ring Cell Carcinoma in Hyperplastic Polyp

W. L. Zea-Iriarte Second Dept. of Internal Medicine, Nagasaki University School of Medicine, and Dept. of Internal Medicine, Sasebo Municipal General Hospital, Nagasaki, Japan; First Dept. of Pathology, Niigata University School of Medicine, Niigata, Japan

M. Itsuno Second Dept. of Internal Medicine, Nagasaki University School of Medicine, and Dept. of Internal Medicine, Sasebo Municipal General Hospital, Nagasaki, Japan; First Dept. of Pathology, Niigata University School of Medicine, Niigata, Japan

K. Makiyama Second Dept. of Internal Medicine, Nagasaki University School of Medicine, and Dept. of Internal Medicine, Sasebo Municipal General Hospital, Nagasaki, Japan; First Dept. of Pathology, Niigata University School of Medicine, Niigata, Japan

K. Hara Second Dept. of Internal Medicine, Nagasaki University School of Medicine, and Dept. of Internal Medicine, Sasebo Municipal General Hospital, Nagasaki, Japan; First Dept. of Pathology, Niigata University School of Medicine, Niigata, Japan

M. Haraguchi Second Dept. of Internal Medicine, Nagasaki University School of Medicine, and Dept. of Internal Medicine, Sasebo Municipal General Hospital, Nagasaki, Japan; First Dept. of Pathology, Niigata University School of Medicine, Niigata, Japan

Y. Ajioka Second Dept. of Internal Medicine, Nagasaki University School of Medicine, and Dept. of Internal Medicine, Sasebo Municipal General Hospital, Nagasaki, Japan; First Dept. of Pathology, Niigata University School of Medicine, Niigata, Japan

Abstract

Background: A polypectomy was performed on a 68-year-old woman who had three gastric hyperplastic polyps. A focal signet ring cell carcinoma was discovered in one of the polyps, which was 2.2 cm in diameter and was located in the antrum. Methods: To study the carcinoma's phenotypic expression, special mucin histochemical stainings were performed. Results: The carcinoma infiltrated only into the mucosa. Intestinal metaplasia was scant. In the neoplasm neutral and foveolar mucin was predominant over acid mucin. The surrounding hyperplastic foveolar epithelium showed positivity for neutral mucin, and the intestinal metaplasia foci for acid mucin. Conclusions: This neoplasm has a mixed composition of mucins and shares histochemical characteristics with the surrounding hyperplastic foveolar epithelium.

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Signet Ring Cell Carcinoma in Hyperplastic Polyp

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Signet Ring Cell Carcinoma in Hyperplastic Polyp

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