Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

Yasuhiro TsujiDepartment of Pharmacy, Sasebo Chuo Hospital, Sasebo, NagasakiCorrespondence[email protected]

Yoichi HirakiDepartment of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto

Kana MatsumotoDepartment of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto

Akiko MizoguchiDepartment of Pharmacy, Sasebo Chuo Hospital, Sasebo, Nagasaki

Shinichi SadohDepartment of Pharmacy, Sasebo Chuo Hospital, Sasebo, Nagasaki

Tsutomu KobayashiDepartment of Internal Medicine, Sasebo Chuo Hospital, Sasebo, Nagasaki

Yusuke TakemuraDepartment of Neurosurgery, Sasebo Chuo Hospital, Sasebo, Nagasaki

Seisaburo SakamotoDepartment of Neurosurgery, Sasebo Chuo Hospital, Sasebo, Nagasaki

Kunihiko MoritaDepartment of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto

Hidetoshi KamimuraDepartment of Pharmaceutical and Health Care Management, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka

Yoshiharu KarubeLaboratory of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan

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Abstract

We describe a case of bacterial meningitis in a patient administered linezolid (LZD). The ratio of free to total LZD concentrations in cerebrospinal fluid (CSF) was 1 for all measurements, and the LZD concentration in CSF measured at the trough level was almost the same as the free serum concentration.

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Declaration of interest: Funding was provided by institutional sources only. None of the authors have a conflict of interest to declare.

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Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

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Pharmacokinetics and protein binding of linezolid in cerebrospinal fluid and serum in a case of post-neurosurgical bacterial meningitis

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