Outbreak caused by Proteus mirabilis isolates producing weakly expressed TEM-derived extended-spectrum β-lactamase in spinal cord injury patients with recurrent bacteriuria

Lise CremetService de Bactériologie-Hygiène, CHU de Nantes;Université de Nantes, EA3826, Thérapeutiques Cliniques et Expérimentales des Infections, UFR de Médecine

Pascale BemerService de Bactériologie-Hygiène, CHU de Nantes

Joanna RomeService de Médecine Physique et Réadaptation Neurologique, Hôpital Saint-Jacques, CHU de Nantes

Marie-Emmanuelle JuvinService de Bactériologie-Hygiène, CHU de Nantes

Dominique NavasService de Pharmacie, CHU de Nantes

Celine BourigaultService de Bactériologie-Hygiène, CHU de Nantes

Aurelie GuillouzouicService de Bactériologie-Hygiène, CHU de Nantes;Université de Nantes, EA3826, Thérapeutiques Cliniques et Expérimentales des Infections, UFR de Médecine

Nathalie CaroffUniversité de Nantes, EA3826, Thérapeutiques Cliniques et Expérimentales des Infections, UFR de Médecine

Didier LepelletierService de Bactériologie-Hygiène, CHU de Nantes;Université de Nantes, EA3826, Thérapeutiques Cliniques et Expérimentales des Infections, UFR de Médecine

Nathalie AsserayUniversité de Nantes, EA3826, Thérapeutiques Cliniques et Expérimentales des Infections, UFR de Médecine;Référent en Antibiothérapie, CHU de Nantes, Nantes, France

Brigitte Perrouin-VerbeService de Médecine Physique et Réadaptation Neurologique, Hôpital Saint-Jacques, CHU de Nantes

Stephane CorvecService de Bactériologie-Hygiène, CHU de Nantes;Université de Nantes, EA3826, Thérapeutiques Cliniques et Expérimentales des Infections, UFR de MédecineCorrespondence[email protected]

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Abstract

We performed a retrospective extended-spectrum β-lactamase (ESBL) molecular characterization of Proteus mirabilis isolates recovered from urine of spinal cord injury patients. A incorrectly detected TEM-24-producing clone and a new weakly expressed TEM-derived ESBL were discovered. In such patients, ESBL detection in daily practice should be improved by systematic use of a synergy test in strains of P. mirabilis resistant to penicillins.

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Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Outbreak caused by Proteus mirabilis isolates producing weakly expressed TEM-derived extended-spectrum β-lactamase in spinal cord injury patients with recurrent bacteriuria

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Outbreak caused by Proteus mirabilis isolates producing weakly expressed TEM-derived extended-spectrum β-lactamase in spinal cord injury patients with recurrent bacteriuria

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