Correlation between serum linezolid concentration and the development of thrombocytopenia

Abstract

We evaluated the possible association between trough linezolid (LZD) concentrations and platelet counts using a dose–response curve with a logit model equation. We demonstrated that trough LZD concentrations correlated with platelet counts. A significant decrease in platelet count was observed in patients with trough LZD concentrations higher than 22.1 μg/ml.

Keywords::

• Dose–response curve
• linezolid
• logit analysis
• renal dysfunction
• thrombocytopenia

Declaration of interest The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.