Two cases of hemolytic uremic syndrome caused by Streptococcus pneumoniae serotype 3, one being a vaccine failure

Daniel NovakDepartment of Pediatrics, Queen Silvia Children's Hospital Gothenburg, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenCorrespondence[email protected]

Anna LundgrenGothenburg University Vaccine Research Institute (GUVAX), Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden

Susanne WestphalDepartment of Pediatrics, Queen Silvia Children's Hospital Gothenburg, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Sindri ValdimarssonDepartment of Pediatrics, Queen Silvia Children's Hospital Gothenburg, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Martin L. OlssonDivision of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden

Birger TrollforsDepartment of Pediatrics, Queen Silvia Children's Hospital Gothenburg, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Abstract

We report two cases of Streptococcus pneumoniae-associated hemolytic uremic syndrome (SP-HUS) caused by serotype 3. One case occurred in an unvaccinated boy and 1 in a girl vaccinated with the 13-valent pneumococcal conjugate vaccine. SP-HUS must be considered in children, and conjugate vaccines may be less effective against serotype 3 than other serotypes.

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Acknowledgements

We thank Annika Hult and Jill Storry, Lund, for performing the flow cytometry and agglutination assays, respectively. Financial support was obtained by the Västra Götaland region.

Declaration of interest: No conflicts of interest.

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Two cases of hemolytic uremic syndrome caused by Streptococcus pneumoniae serotype 3, one being a vaccine failure

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