Neonatal transfusion-transmitted hepatitis C virus infection following a pre-seroconversion window-phase donation in Sweden

Jesper Waldenström From the Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg

Jan KonarDepartment of Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg

Bengt EkermoDepartment of Clinical Immunology and Transfusion Medicine, County Council of Östergötland, Linköping University, Sweden

Helene Norder From the Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg

Martin Lagging From the Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of GothenburgCorrespondence[email protected]

Abstract

A 9-day-old child developed a transfusion-transmitted hepatitis C virus (HCV) infection following a pre-seroconversion window-phase donation. Retrospective analysis of donor plasma revealed detectable HCV core antigen (154 fmol/l), as well as HCV RNA (87,000 IU/ml). Of 5.24 million Swedish plasma samples from December 1998 to September 2012, 5 additional window-phase donations were identified.

Keywords::

Declaration of interest: None of the authors have any conflict of interest.

This study was supported by The Swedish Medical Research Council (grant 2011-3821) and ALF Funds (grant ALFGBG-3149).

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Neonatal transfusion-transmitted hepatitis C virus infection following a pre-seroconversion window-phase donation in Sweden

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Neonatal transfusion-transmitted hepatitis C virus infection following a pre-seroconversion window-phase donation in Sweden

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