Isolation and Propagation of Nephropathia Epidemica Virus in Bank Voles

Richard Yanagihara Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

Arne Svedmyr Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

Herbert L. Amyx Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

Pyungwoo Lee Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

Dmitry Goldgaber Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

D. Carleton Gajdusek Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

Clarence J. Gibbs Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

Kurtny Ström Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, USA; National Institutes of Health, Bethesda, Maryland, USA; Central Microbiology Laboratory, the Stockholm County Council, Stockholm, Sweden; Department of Medicine, University of Umeå, Umeå, Sweden

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Abstract

Three strains of nephropathia epidemica (NE) virus were isolated from lung tissues of bank voles (Clethrionomys glareolus) and a grey-sided vole (C. rufocanus) trapped in Västerbotten county, Sweden. Two of these isolates were serially passaged in seronegative laboratory-bred bank voles. Experimentally infected animals developed a subclinical infection characterized by virus persistence, particularly in lung tissue. Attempts to infect other species of colonized rodents with NE virus and to isolate NE virus from acute phase patient blood were unsuccessful. The serial propagation of NE virus in colonized bank voles provides opportunities to study experimental infection in its reservoir rodent host.

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Isolation and Propagation of Nephropathia Epidemica Virus in Bank Voles

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Isolation and Propagation of Nephropathia Epidemica Virus in Bank Voles

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