Lymphocyte Immunoglobulin Secretion during Short-term Treatment with Cephalosporins in Vivo and in Vitro: Effects on Plaque-forming Cell Response of Human Peripheral Blood Lymphocytes

Abstract

The influence of 4 cephalosporins on the plaque-forming cell (PFC) generation in mitogen-activated cultures of human lymphocytes (PBL) was assessed. In vitro, suprapharmacological concentrations of the drug resulted in a decreased PFC response, while pharmacological concentrations did not influence the generation of PFC. Cells exposed to drugs for 24 h in vivo and propagated in autologous serum in vitro showed a decreased PFC response.