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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 1
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Research Article

In Vitro Metabolism of Dimethylaminopropylthio-cinnamanilide (SQ 16,167) and its Methylureido Analogue (SQ 11,447)

K. K. Wong Department of Drug Metabolism, Squibb Institute for Medical Research, New Brunswick, New Jersey, 08903, USA
,
J. Dreyfuss Department of Drug Metabolism, Squibb Institute for Medical Research, New Brunswick, New Jersey, 08903, USA
&
E. C. Schreiber Department of Drug Metabolism, Squibb Institute for Medical Research, New Brunswick, New Jersey, 08903, USA
Pages 25-27 | Received 15 Jan 1971, Published online: 15 Sep 2008
 
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Abstract

The amide bond of (trans-2′-(3-dimethylaminopropylthio)cinnamanilide (SQ 16,167), but not that of its methylureido analogue, (SQ 11,447) is cleaved in vitro by liver homogenates of the rat, dog, and human.

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