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Abstract
1. The predominant site for the hepatic reduction of aromatic and aliphatic ketones is the cytosol.
2. Compounds in which at least one aromatic ring is adjacent to the carbonyl group are reduced to aryl-alkyl or aryl-aryl carbinols in NADPH-requiring reactions, whereas either NADH or NADPH serves as cofactor in the analogous reaction with aliphatic ketones.
3. Acetophenone reductase activity is not enhanced in liver cytosol after treatment of rats with phenobarbital.
4. Ketone reductase activity was found in the cytosol fractions of some non-hepatic tissues, particularly in that of kidney.