A multi-dose study on the human metabolism of amylobarbitone

Abstract

1. The metabolism of amylobarbitone has been investigated in two healthy male volunteers, and the urinary excretion of unchanged drug, and the products of ω and ω - 1 oxidation, quantitatively determined for four days after each of three doses to each volunteer.

2. In contrast to observations with butobarbitone, amylobarbitone was shown to have little effect on the rate of its own metabolism.

3. The t_1/2 for urinary excretion of the parent drug was 16.3 h while that for the two metabolites was 22.2 h.