Effect of a terpenoid, (—)-6-Hydroxy-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol, on drug-metabolizing enzymes and glutathione content in rat liver and lung

Abstract

1. Chronic treatment of Sprague-Dawley rats with the new terpenoid mucoregulating drug (I) did not modify activities of the drug-metabolizing enzymes (phase I and phase II) of liver and lung.

2. Acute treatment of rats with I did not affect the GSH content of liver and lung, but administration of the corresponding α, β-unsaturated ketone (II) produced considerable GSH depletion in both tissues, the original GSH levels being restored after a few hours.

3. The results are discussed in comparison with those previously obtained with the structurally related drug trans-sobrerol (III).