Anti-microbial activity of amniotic fluid β-lysin and the influence of zinc ion

L. C. Ford Departments of Obstetrics and Gynecology and Biological Chemistry, Center for the Health Sciences, University of California, Los Angeles, California

W. Kasha Departments of Obstetrics and Gynecology and Biological Chemistry, Center for the Health Sciences, University of California, Los Angeles, California

Karen L. Singer Departments of Obstetrics and Gynecology and Biological Chemistry, Center for the Health Sciences, University of California, Los Angeles, California

R. J. De Lange Departments of Obstetrics and Gynecology and Biological Chemistry, Center for the Health Sciences, University of California, Los Angeles, California

T. B. Lebherz Departments of Obstetrics and Gynecology and Biological Chemistry, Center for the Health Sciences, University of California, Los Angeles, California

G. Alexander Departments of Obstetrics and Gynecology and Biological Chemistry, Center for the Health Sciences, University of California, Los Angeles, California

Summary

Amniotic fluid β-lysin was found to have zinc-dependent bacteriostatic activity against the enteric bacilli, anaerobic Gram-negative bacilli and Gram-positive aerobic and anaerobic cocci. In contrast, β-lysin was found to exhibit bactericidal activity against the anaerobic and aerobic Gram-positive bacilli. This bactericidal activity was independent of zinc ion concentration. The clinical and biochemical implications of these observations are discussed.

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