Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs

Abstract

The aim of this study was to determine the safety of imidocarb dipropionate in sheep. Imidocarb dipropionate (IMDP) was administered (2.4 mg/kg, intramuscular; i.m.) to 10 sheep, and blood samples were obtained 0, 1, 6, and 9 days after treatment. Hemacell counts, serum biochemical values, coagulation values, and serum oxidative status were measured. IMDP caused transient decreases in pH, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, lactate dehydrogenase, and retinol levels and transient increases in serum creatine kinase–MB, blood urea nitrogen, and creatinine levels. IMDP decreased adenosine deaminase activity, antithrombin III, and superoxide dismutase activity and increased white blood cell counts. In conclusion, IMDP may change serum oxidative status and cause coagulation disorders during treatment in sheep.

Keywords::

• Imidocarb dipropionate
• safety
• lamb

Acknowledgments

The authors thank Dr. Aziz Bulbul and Ayse Er for assaying antioxidant status and routine biochemical values.

Declaration of interest

The authors report no financial conflicts of interest. The authors alone are responsible for the content and writing of this paper.